Hepatitis C
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Articles by
Dr. Zhang
 
TCM and MCM Theory Related to Common Liver Disease Blood Test Markers

Low Dose Interferon Patient Experiment

Hepatitis A Prevention Reminder

Hepatitis: Causes of Pain in Liver Region 

The Need to Monitor Your Chronic Hepatitis

Liver Enzyme Fluctuation during Allergy Season 

What are the Serum Markers of Hepatitis B and What do They Mean?

Enterogenous Endotoxemia in Chronic Hepatitis–
Part 2

Enterogenous Endotoxemia in Chronic Hepatitis–
Part 1
 

Chronic Hepatitis and "Blood Activating and Stasis Expelling" (BASE) Therapy -
Part 2

Chronic Hepatitis and "Blood Activating and Stasis Expelling" (BASE) Therapy
Part 1

What Causes Gastrointestinal Bleeding in Cirrhotic Liver Disease

Dietary Support for Cirrhotic Liver Diseases

Ascites - A Complication of De-Compensated Liver Cirrhosis

Liver Cirrhosis - Portal Vein Hypertension Complications

Liver Cirrhosis Overview

PG-IFN and Ribavirin Treatments

Antibiotics and Chronic Liver Diseases

Why is Alcohol Harmful for People with Hepatitis?

Co-infections and Super-infections of Viral Hepatitis

Beware of Medications That Can Cause Liver Damage

Bile Retention and Its Clinical Manifestations (MCM) part 4

Modern Chinese Medicine (MCM) Part 3 
Jaundice and Chronic Viral Hepatitis

Modern Chinese Medicine (MCM) Anti-Liver-Fibrosis Treatments - Part 2

Modern Chinese Medicine (MCM) Anti-Liver-Fibrosis Treatments - Part 1

What is Liver Fibrosis and How is It Different from Cirrhosis?

How does the liver change as we get older?

How is that my LFTs are so good when my viral load is seemly so high?

Comprehensive Care for Chronic Viral Hepatitis

What can Cause Liver Inflammation?  

What Are the Major Functions that the Liver Carries?


 





Beware of Medications that can Cause Liver Damage

Liver damage and disease can be caused by the effects of drug or its metabolites, called iatrogenic (medication caused). In recent years, with the increasing number of drugs, this kind of liver diseases is increasing rapidly as more than 200 drugs are known to cause iatrogenic liver diseases (ILD).

The frequency of liver damages is third in line, next to skin reactions and iatrogenic fever and acute ILD made up 10% of the total acute liver diseases in hospitalized emergency cases.  According to a Japanese study, which analyzed 13,738 cases of ILD reported in medical journals, found that in 1990s, the most frequent drug related liver damages were caused by antibiotics (36.3%). The frequency of iatrogenic antibiotics reaction is in following sequence: cefaloridine, cefalexin, and penicillin family (especially ampicillin.)

Anti-cancer drugs were the second most common categories in causing ILD, such as tagfur, methootrexate (MTX), and cytoxan. 

The third most common causes of ILD were drugs used for diseases of central nerve system, including general anesthesia drugs and helothane. Next were pain-killers, such as aspirin, indomethacin, and wintermin.

The fourth category of drugs that caused ILD was drugs used for cardiovascular systems, such as agmaline, methyldopa, trapidil, etc. 

The fifth categories were chemical treatments, such sulfonamide, and anti-tuberculosis drugs.

At the end of 1990s, the frequency of these categories has changed a bit. Antibiotics was still at the top; second being drugs for the central nerve system; third being cardiovascular drugs the; fourth being anti-cancer treatment and general chemical treatment being the fifth.

In the western countries, the situation was different. Denmark, in 1982, three drugs caused the most ILD and they were halothane, wintermin, and oral contraceptive. 1996, in the UK, there were total 1,600 cases of ILD, which was 3.5% of the total liver diseases, and the three most frequent causes were general anesthesia drugs such as halothane, antibiotics, and oral contraceptives.
In order to diagnose ILD, there must be a history of medication. Liver enzyme levels usually start to rise after one to four weeks on the medication. The first symptoms were fever, rashes, and skin itch, and jaundice. In the complete blood counting, WBC will increase, especially eosinocyte increase. Allergic test for this drug will also be positive. If reused, the ILD can happen again and if histological tests were done, the liver could show bile retention and liver cell damage.

When ILD occurs, the first thing to do is stop the drug intake immediately.  In order to avoid iatrogenic liver disease, the principle is to stop taking any unnecessary medications. When you visit doctors for conditions other than the liver, be sure tell your doctor that you have hepatitis C and ask him/her whether the medication you are going to get is harmful to the liver. Avoid self-medication, especially long-term use of over-the-counter medications, since you may not know what is exactly contained in the drug and the labels might not provide the necessary information. In any case, if you can find any replacement of drugs by non-toxic natural supplements, it would be preferable to use non-chemical supplements.

From our treatment's prospective, we offer safe and effective alternatives such as Allicin, for eliminating infections, and Herbsom for sleeping difficulties.

Medication can also causes acute allergic injuries to the liver. The mechanism is usually the drug serving as a hapten (semi-antigen), which combines with serum protein to form hapten-carrier-complex, which causes cellular immune reactions. These reactions can also cause liver damage. In drugs that cause allergic reactions in the liver, the symptoms consist of 52% with fever, 48% with skin rashes, 64% with skin itch, and 73% with jaundice.
Again, the first thing to do is to stop the medication as soon as possible. In our herbal remedies, we can use AI #3 Capsule to suppress the allergic reactions caused by immune response.

As a general rule, it is best to let your practitioner know about your liver condition when being treated for other conditions. Medications come in many forms and it is best to find out what is in them and what it can do to your liver.

 

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About HCV
Overview
Causes and Transmission

 
Diagnostic Tests
Antibody
HCV RIBA
HCV RNA 
Viral Load

Viral Genotyping

 
Major Signs
Liver Inflammation
Fibrosis
Cirrhosis

 
Peripheral Signs and Symptoms
Fatigue
Jaundice
Bile Retention
Joint Pains and Skin Rashes
Blood Sugar Instability
Portal Vein Hypertension
Ascites

 
Important Liver Function Test Markers
Overview
ALT and AST
ALP and GGT
Albumin
Bilirubin
PT (Prothrombin Time)
 
Liver Biopsy
Overview
Procedure
Inflammation Grade
Fibrosis Stage
 
Interferon Based Treatment
Overview
Ideal Candidate
Possible Side-effects
 
Liver Support with TCM
Overview
Liver Enzymes
Serum Albumin
Blood Clotting Factors
Bile metabolism
GGT
 
Dietary Considerations
Overview
Proteins
Essential Fats
Carbohydrates
Vitamins
 
 

 


 

 

Medical Information Sources:
http://www.nih.gov/
http://www.nlm.nih.gov/

http://nccam.nih.gov/
http://www.medlineplus.org/


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