Liver Biopsy
Inflammation Grade |
Liver biopsy provides the
best information available concerning the amount of hepatic fibrosis and
the amount of ongoing inflammation and necrosis. Inflammation is
characteristically predominantly located in the portal area and consists
of a mixture of mononuclear cells and lymphocytes. In more severe cases,
inflammation and necrosis of the lobular parenchyma is present.
One grading system used
for assessing inflammation and fibrosis is that of Batts and Ludwig.(3)
|
0 |
No activity |
None |
None |
|
1 |
Minimal |
Minimal,
patchy |
Minimal;
occasional spotty necrosis |
|
2 |
Mild |
Mild;
involving some or all portal tracts |
Mild; little
hepatocellular damage |
|
3 |
Moderate |
Moderate;
involving all portal tracts |
Moderate;
with noticeable hepatocellular damage |
|
4 |
Severe |
Severe; may
have bridging fibrosis |
Severe, with
prominent diffuse hepatocellular damage |
|
SOURCE: Batts and Ludwig (Am J Surg
Pathol 1995) (Table)
Batts KP, Ludwig J. Chronic hepatitis. An update on terminology and
reporting. Am J Surg Pathol 1995;19(12): 1409-17.
|
